Age‐related effects of Mycoplasma pneumoniae infection and subsequent asthma exacerbation in children

Abstract Background Mycoplasma pneumoniae causes community‐acquired pneumonia in children and increases asthma risk, but large studies are lacking. Objective To assess the link between M. pneumoniae infection and to asthma exacerbation, in children with allergies, and age of infection impact. Methods This retrospective cohort study analyzed medical records of South Korean children between January 2002 and December 2017. The study's exposure was hospitalization with an M. pneumoniae ‐related diagnosis, and the outcome was defined as asthma exacerbation, confirmed by hospitalization at least 6 months after M. pneumoniae infection, with alternative validation using asthma diagnosis and systemic steroid prescription records. Hazard ratios (HRs) for asthma exacerbation risk were estimated for the matched cohort using a Cox proportional hazards model stratified by allergic comorbidities. Time‐dependent covariates and age‐stratified exposure groups were used to calculate odds ratios. Results The study included 84,074 children with M. pneumoniae infection and 336,296 unexposed children. Follow‐up for 12.2 ± 2.3 years found the exposed group had a significant risk of asthma exacerbation (HR 2.86, 95% confidence interval [CI] 2.67−3.06) regardless of allergic comorbidities. The risk was highest (over threefold) in children infected between 24 and 71 months. Sensitivity analysis using an alternative definition of the outcome showed an HR of 1.38 (95% CI 1.35−1.42), further supporting the association between M. pneumoniae infection and asthma exacerbation. Conclusion M. pneumoniae infection was significantly associated with an increased risk of subsequent asthma exacerbation regardless of allergic comorbidities. Further research needed for understanding and confirmation.