Fibroblast-immune crosstalk under mechanical forces in keloids

Our letter in response to Min et al.’s study ‘Novel therapeutic strategy for intractable keloids: suppression of intracellular mechanotransduction and actin polymerization via Rho-kinase pathway inhibition’ highlights the importance of immune-cell interactions with mechanical forces in keloid pathogenesis. While the authors effectively demonstrate the potential of inhibiting mechanotransduction in fibroblasts, we underscore the critical role of immune cells, particularly their response to ECM stiffness, in modulating fibrosis and suggest this crosstalk may reveal additional therapeutic targets.