已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Investigation of Algerian Crataegus monogyna Jacq Phenolic Compounds (Using LC-ESI-MS/MS Analysis, Antioxidant Activity, and Enzyme Inhibition) and Their Potential Implications for Food and Nutraceutical Applications

保健品 抗氧化剂 化学 传统医学 山楂 食品科学 多酚 生物化学 医学
作者
Sabrina Goudjil,Samira Boussekine,Sarra Goudjil,Hanane Goudjil,Mustafa Abdullah Yılmaz,Mohammad Shamsul Ola,Ahmad Ali,Oğuz Çakır
出处
期刊:Antioxidants [MDPI AG]
卷期号:13 (11): 1350-1350 被引量:2
标识
DOI:10.3390/antiox13111350
摘要

Investigations into the phenolic constituents of the butanolic fraction of Crataegus monogyna were optimized using LC-ESI-MS/MS analysis, identifying and quantifying at least 23 fingerprint phytochemical compounds. The major phenolic compounds were epicatechin (99.916 ± 2.208 mg/g), isoquercetrin (53.31 ± 1.172 mg/g), chlorogenic acid (47.457 ± 1.010 mg/g), quinic acid (37.819 ± 1.406 mg/g), rutin (29.98 ± 0.740 mg/g), hesperidin (5.296 ± 0.177 mg/g, detected for the first time in the C. monogyna species), astragalin (1.774 ± 0.020 mg/g), and nicotiflorin (1.482 ± 0.016 mg/g). The antioxidant properties of the lyophilized butanolic fraction were evaluated using DPPH, GOR, ABTS, CUPRAC, and reducing power assays, all of which demonstrated that there was strong activity. Additionally, the neuroprotective effect was evaluated in vitro, showing a potent inhibitory effect on acetylcholinesterase (AChE) with an IC50 of 43.65 ± 2.10 µg/mL. The antidiabetic effect was investigated through α-amylase inhibition (IC50 = 91.19 ± 0.10 µg/mL), showing high inhibitory activity. In addition, the butanolic extract exhibited significant urease inhibition with an IC50 of 26.36 ± 0.05 µg/mL. These results suggest that Algerian C. monogyna has potential as a therapeutic agent for managing diabetes complications and as a natural source of AChE inhibitors, making it a promising subject for the treatment of urease-related conditions. Its high concentrations of natural antioxidants, such as epicatechin, isoquercetrin, chlorogenic acid, quinic acid, rutin, hesperidin, and astragalin, make it suitable for integration into medicine, pharmaceuticals, cosmetics, and the food sector.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
研友_VZG7GZ应助佳仔采纳,获得10
1秒前
冬冬完成签到,获得积分10
1秒前
2秒前
镜哥完成签到,获得积分10
4秒前
打打应助干净问筠采纳,获得10
4秒前
乐乐应助平淡的帆布鞋采纳,获得10
5秒前
Pepsi发布了新的文献求助10
7秒前
xiaozhao完成签到,获得积分10
7秒前
乐乐应助干净问筠采纳,获得10
11秒前
11秒前
鲁丁丁完成签到 ,获得积分10
13秒前
娜娜发布了新的文献求助10
16秒前
斯文败类应助捏个小雪团采纳,获得10
18秒前
19秒前
华仔应助娜娜采纳,获得10
23秒前
科研通AI5应助干净问筠采纳,获得10
23秒前
24秒前
友好大树发布了新的文献求助30
25秒前
xyydhcg完成签到,获得积分20
26秒前
科研通AI5应助tang采纳,获得10
26秒前
雍雍完成签到 ,获得积分10
29秒前
35秒前
科研通AI5应助冷酸灵采纳,获得10
36秒前
最棒哒完成签到 ,获得积分10
36秒前
希望天下0贩的0应助Echo采纳,获得10
37秒前
疯狂喵完成签到 ,获得积分10
40秒前
Honghao发布了新的文献求助10
42秒前
43秒前
adkdad完成签到,获得积分10
45秒前
冷酸灵发布了新的文献求助10
49秒前
受伤书文完成签到,获得积分10
50秒前
Orange应助yyy采纳,获得10
51秒前
51秒前
老迟到的书雁完成签到 ,获得积分10
54秒前
56秒前
Lucas应助友好大树采纳,获得30
56秒前
57秒前
时尚丹寒完成签到 ,获得积分10
57秒前
西伯利亚大蟑螂完成签到,获得积分20
57秒前
Zn应助swordlee采纳,获得10
58秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Structural Load Modelling and Combination for Performance and Safety Evaluation 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3555605
求助须知:如何正确求助?哪些是违规求助? 3131310
关于积分的说明 9390527
捐赠科研通 2830903
什么是DOI,文献DOI怎么找? 1556204
邀请新用户注册赠送积分活动 726475
科研通“疑难数据库(出版商)”最低求助积分说明 715803