胸腺基质淋巴细胞生成素
免疫系统
免疫学
细胞因子
造血干细胞移植
移植
流式细胞术
干细胞
间质细胞
移植物抗宿主病
医学
生物
内科学
细胞生物学
作者
Dina Leth Møller,Katrine Kielsen,Claus Henrik Nielsen,Henrik Sengeløv,Anders Elm Pedersen,Lars P. Ryder,Klaus Müller
标识
DOI:10.1080/08923973.2022.2102989
摘要
Thymic stromal lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity.We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.TSLP levels rose after initiation of the conditioning to peak at day +21 after HSCT (p = .03), where TSLP levels correlated with counts of neutrophils (rho = 0.36, p = .04), monocytes (rho = 0.58, p = .006), and lymphocytes (rho = 0.59, p = .02). Overall absolute TSLP levels were not associated with acute or chronic graft-vs-host disease (a/cGvHD). However, patients mounting a sustained increase in TSLP levels at day +90 had a higher risk of cGvHD compared to patients who had returned to pre-conditioning levels at that stage (cumulative incidence: 77% vs. 38%, p = .01).In conclusion, this study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT. lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.
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