自愈水凝胶
3D打印
材料科学
流变学
纳米技术
计算机科学
软质材料
3D生物打印
墨水池
透明质酸
3d打印机
组织工程
生物加工
生物医学工程
复合材料
机械工程
高分子化学
工程类
生物
遗传学
作者
Aitor Díaz,Helena Herrada‐Manchón,Juliana de Souza Nunes,Aitziber Lopez Elorza,Natividad Díaz,Hans‐Jürgen Grande,Iraida Loinaz,Manuel Fernández,Damien Dupin
标识
DOI:10.1002/marc.202200449
摘要
Abstract 3D printing technology offers a vast range of applications for tissue engineering applications. Over the past decade a vast range of new equipment has been developed; while, 3D printable biomaterials, especially hydrogels, are investigated to fit the printability requirements. The current candidates for bioprinting often require post‐printing cross‐linking to maintain their shape. On the other hand, dynamic hydrogels are considered as the most promising candidate for this application with their extrudability and self‐healing properties. However, it proves to be very difficult to match the required rheological in a simple material. Here, this study presents for the first time the simplest formulation of a dynamic hydrogel based on thiol‐functionalized hyaluronic acid formulated with gold ions that fulfill all the requirements to be printed without the use of external stimuli, as judged by the rheological studies. The printability is also demonstrated with a 3D printer allowing for the printing of the dynamic hydrogel as it is, achieving 3D construct with a relatively good precision and up to 24 layers, corresponding to 10 mm high. This material is the simplest 3D printable hydrogel and its mixture with cells and biological compounds is expected to open a new era in 3D bioprinting.
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