泛素连接酶
干扰素
生物
免疫系统
泛素
髓样
干扰素调节因子
调解人
信号转导
免疫学
癌症研究
基因
先天免疫系统
细胞生物学
遗传学
作者
Wei Sun,Xin Hua,Yanli Gu,Qiuli Xu,Suhua Zhu,Tangfeng Lv,Yong Song
标识
DOI:10.1016/j.clim.2022.109099
摘要
Interferon signaling is closely associated with clearance of viral infections as well as the development of systemic lupus erythematosus (SLE). Therefore, from a clinical perspective, it is important to identify the key regulators involved in interferon signaling pathways. In this study, we identified that RNF6, as an interferon inducible E3 ubiquitin ligase, promoted the interferon-dependent antiviral response. Knock-down of RNF6 greatly attenuated expression of ISGs and the transcriptional activity of ISRE. Specifically, increased RNF6 expression in myeloid cells of patients with SLE correlated with high expression of ISGs. Our results uncover RNF6 as a positive mediator in the antiviral immune responses and suggest that RNF6 may contribute to predict interferon signaling in SLE.
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