Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats

心肌保护 内科学 内分泌学 高强度间歇训练 心功能曲线 硫代巴比妥酸 肌酸 心室 医学 氧化应激 丙二醛 脂质过氧化 缺血 心力衰竭
作者
Veljko Prokic,Marina Rankovic,Nevena Draginić,Marijana Andjić,Jasmina Sretenovic,Vladimir Živković,Jovana Jeremić,Milica Milinkovic,Sergey Bolevich,Vladimir Jakovljević,Suzana Pantović
出处
期刊:Canadian Journal of Physiology and Pharmacology [NRC Research Press]
卷期号:100 (8): 772-786 被引量:1
标识
DOI:10.1139/cjpp-2021-0801
摘要

This study aimed to determine how guanidinoacetic acid (GAA) or its combined administration with betaine (B) or creatine (C) influences the cardiac function, morphometric parameters, and redox status of rats subjected to high-intensity interval training (HIIT). This research was conducted on male Wistar albino rats exposed to HIIT for 4 weeks. The animals were randomly divided into five groups: HIIT, HIIT + GAA, HIIT + GAA + C, HIIT + GAA + B, and HIIT + GAA + C + B. After completing the training protocol, GAA (300 mg/kg), C (280 mg/kg), and B (300 mg/kg) were applied daily per os for 4 weeks. GAA supplementation in combination with HIIT significantly decreased the level of both systemic and cardiac prooxidants ([Formula: see text], H 2 O 2 , [Formula: see text], and thiobarbituric acid reactive substances) compared with nontreated HIIT ( p < 0.05). Also, GAA treatment led to an increase in glutathione and superoxide dismutase levels. None of the treatment regimens altered cardiac function. A larger degree of cardiomyocyte hypertrophy was observed in the HIIT + GAA group, which was reflected through an increase of the cross-sectional area of 27% ( p < 0.05) and that of the left ventricle wall thickness of 27% ( p < 0.05). Since we showed that GAA in combination with HIIT may ameliorate oxidative stress and does not alter cardiac function, the present study is a basis for future research exploring the mechanisms of cardioprotection induced by this supplement in an HIIT scenario.
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