Jan Vijg1 and Steven N. Austad2 1Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA 2Protective Life Endowed Chair in Healthy Aging Research, Department of Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35233, USA Correspondence: jan.vijg{at}einsteinmed.edu; austad{at}uab.edu