纳米器件
适体
受体
纳米技术
分子识别
生物物理学
化学
模块化设计
材料科学
计算机科学
生物
分子
生物化学
遗传学
操作系统
有机化学
作者
Zhimin Wang,Sitao Xie,Limei Wu,Fengming Chen,Liping Qiu,Weihong Tan
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-09-20
卷期号:22 (19): 7853-7859
被引量:15
标识
DOI:10.1021/acs.nanolett.2c02522
摘要
The capacity to regulate the signaling amplitude of membrane receptors in a user-defined manner would open various opportunities for precise biological study and therapy. While partial agonists enabled downtuning of cellular responses, they required esoteric optimization of the ligand-receptor interface, limiting their practical applications. Herein, we developed an aptamer-functionalized, tweezer-like nanodevice to dynamically modulate the cellular behavior through control over the distance between receptors in the dimer with no need to involve complicated structural analysis. By combining a reversible conformation switch with aptamer-based molecular recognition, this nanodevice showed excellent performance on dynamic regulation of CD28 receptor-mediated T cell immunity. With the modular design, this nanodevice could be extended to dynamically modulate the activity of other membrane receptors (e.g., c-Met), expecting to offer a new paradigm for precise study and manipulation of specific molecular events in complex biological systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI