吸光度
剂型
相关系数
色谱法
检出限
甲醇
线性
药物制剂
稳健性(进化)
溶剂
化学
数学
统计
物理
生物化学
有机化学
量子力学
基因
作者
Afnaz Jahan,Mohammad A. Khaleel,Husnain Fathima
出处
期刊:International research journal of pharmacy
[Diva Enterprises Private Limited]
日期:2022-08-06
卷期号:: 279-283
标识
DOI:10.52711/0974-4150.2022.00050
摘要
A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Bilastine in pure drug and tablet dosage form. The absorbance was measured at 226.2nm using Methanol as solvent system. It obeyed Beer’s law at the concentration range of 2-12µg/ml with coefficient of correlation (r2) of 0.9993. Limit of detection (LOD) was found to be 1.224µg/ml and Limit of quantitation (LOQ) was found to be 4.088µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.
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