丙酮酸脱氢酶复合物
神经科学
化学
生物
医学
新陈代谢
生物化学
酶
作者
Vikram Jakkamsetti,Isaac Marin‐Valencia,Qian Ma,Levi B. Good,Tyler Terrill,Karthik Rajasekaran,Kumar Pichumani,Chalermchai Khemtong,M. A. Hooshyar,Chandrasekhar Sundarrajan,Mulchand S. Patel,Robert Bachoo,Craig R. Malloy,Juan M. Pascual
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2019-02-20
卷期号:11 (480)
被引量:62
标识
DOI:10.1126/scitranslmed.aan0457
摘要
Decreased metabolic flux due to deficient mitochondrial pyruvate dehydrogenase causes excitability dysfunction that can be modulated by acetate.
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