Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing

二甲双胍 老化 2型糖尿病 医学 微生物群 糖尿病 机制(生物学) 2型糖尿病 生物信息学 药理学 生物 内科学 内分泌学 认识论 哲学
作者
Francesco Prattichizzo,Angelica Giuliani,Emanuela Mensà,Jacopo Sabbatinelli,Valeria De Nigris,Maria Rita Rippo,Lucia La Sala,Antonio Domenico Procopio,Fabiola Olivieri,Antonio Ceriello
出处
期刊:Ageing Research Reviews [Elsevier]
卷期号:48: 87-98 被引量:79
标识
DOI:10.1016/j.arr.2018.10.003
摘要

Metformin is the first-choice therapy to lower glycaemia and manage type 2 diabetes. Continuously emerging epidemiological data and experimental models are showing additional protective effects of metformin against a number of age-related diseases (ARDs), e.g., cardiovascular diseases and cancer. This evidence has prompted the design of a specific trial, i.e., the Targeting Aging with Metformin (TAME) trial, to test metformin as an anti-ageing molecule. However, a unifying or prevailing mechanism of action of metformin is still debated. Here, we summarize the epidemiological data linking metformin to ARD prevention. Then, we dissect the deeply studied mechanisms of action explaining its antihyperglycemic effect and the putative mechanisms supporting its anti-ageing properties, focusing on studies using clinically pertinent doses. We hypothesize that the molecular observations obtained in different models with metformin could be indirectly mediated by its effect on gut flora. Novel evidence suggests that metformin reshapes the human microbiota, promoting the growth of beneficial bacterial species and counteracting the expansion of detrimental bacterial species. In turn, this action would influence the balance between pro- and anti-inflammatory circulating factors, thereby promoting glycaemic control and healthy ageing. This framework may reconcile diverse observations, providing information for designing further studies to elucidate the complex interplay between metformin and the metabiome harboured in mammalian body compartments, thereby paving the way for innovative, bacterial-based therapeutics to manage type 2 diabetes and foster a longer healthspan.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
牧友桃发布了新的文献求助10
1秒前
1秒前
Hana完成签到 ,获得积分10
1秒前
无情雪曼发布了新的文献求助10
2秒前
smile发布了新的文献求助10
3秒前
3秒前
3秒前
花儿驳回了wkjfh应助
4秒前
Chen完成签到,获得积分10
6秒前
问之完成签到,获得积分10
6秒前
zherrg发布了新的文献求助10
6秒前
专一的孤菱完成签到,获得积分10
7秒前
希望天下0贩的0应助呆呆采纳,获得10
8秒前
李健应助知行合一采纳,获得10
8秒前
Jasper应助smile采纳,获得10
10秒前
小二郎应助smile采纳,获得10
10秒前
李爱国应助毛豆采纳,获得10
10秒前
小王发布了新的文献求助10
10秒前
Wxx发布了新的文献求助10
11秒前
深情安青应助无情雪曼采纳,获得10
11秒前
wicky完成签到,获得积分10
11秒前
小窝发布了新的文献求助10
11秒前
李健的小迷弟应助lucyliu采纳,获得10
11秒前
糊涂的绿茶完成签到,获得积分10
12秒前
传奇3应助默默的巧蕊采纳,获得10
12秒前
13秒前
赘婿应助大胆妖孽采纳,获得10
13秒前
卡卡完成签到,获得积分10
13秒前
NexusExplorer应助Julie采纳,获得10
13秒前
14秒前
烟花应助小伯Eason采纳,获得10
14秒前
14秒前
小马甲应助Siney采纳,获得10
15秒前
彭于晏应助科研通管家采纳,获得10
15秒前
开心元霜发布了新的文献求助20
15秒前
15秒前
上官若男应助科研通管家采纳,获得10
15秒前
NexusExplorer应助科研通管家采纳,获得10
15秒前
yar应助科研通管家采纳,获得10
15秒前
merry完成签到,获得积分10
15秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
CLSI EP47 Evaluation of Reagent Carryover Effects on Test Results, 1st Edition 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3055112
求助须知:如何正确求助?哪些是违规求助? 2711905
关于积分的说明 7428965
捐赠科研通 2356735
什么是DOI,文献DOI怎么找? 1248250
科研通“疑难数据库(出版商)”最低求助积分说明 606641
版权声明 596083