Clinical presentation and follow-up of women affected by Brugada syndrome

医学 Brugada综合征 危险系数 无症状的 置信区间 QRS波群 心脏病学 心源性猝死 内科学
作者
P. Berthome,Romain Tixier,Jean Paul Briand,Olivier Geoffroy,Dominique Babuty,Jacques Mansourati,Laurence Jesel,Jean‐Marc Dupuis,Paul Bru,Florence Kyndt,Béatrice Guyomarch,Aurélie Thollet,Nathalie Béhar,Philippe Mabo,Frédéric Sacher,Vincent Probst,Jean‐Baptiste Gourraud
出处
期刊:Heart Rhythm [Elsevier BV]
卷期号:16 (2): 260-267 被引量:30
标识
DOI:10.1016/j.hrthm.2018.08.032
摘要

Studies in Brugada syndrome (BrS) have mainly consisted of men.The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women.Consecutive BrS patients were enrolled from 1993 and followed prospectively.Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = .001) and less frequently had a spontaneous ECG pattern (107 [22%] vs 398 [36%], respectively; P <.001). During median [25th, 75th percentile] follow-up of 57 [23, 118] vs 62 [22, 113] months (P = .65), arrhythmic events occurred in 12 women (2%) vs 79 men (7%) (P = .0005). Mean age at the first event was 48.6 ± 17.8 years for women vs 43 ± 14.2 years for men (P <.001). Gender was significantly related to cardiac events (hazard ratio [HR] 2.96; 95% confidence interval [CI] 1.6-5.4; P = .0005). In multivariate analysis, event predictors in women were index patient status (HR 10.15; 95% CI 1.7-61.4; P = .01), previous sudden cardiac death (HR 69.4; 95% CI 15-312.5; P <.0001), syncope (HR 6.8; 95% CI 1.4-34.5; P = .02), fragmented QRS (HR 20.2; 95% CI 1.8-228.9; P = .02), and QRS duration >120 ms (HR 4.7; 95% CI 1.2-19.5; P = .03).Women represent a lower-risk group than men among individuals with BrS. In asymptomatic women, fragmented QRS and QRS >120 ms seem to be the only event predictors.
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