Clinical presentation and follow-up of women affected by Brugada syndrome

医学 Brugada综合征 危险系数 无症状的 置信区间 QRS波群 心脏病学 心源性猝死 内科学
作者
P. Berthome,Romain Tixier,Jean Paul Briand,Olivier Geoffroy,Dominique Babuty,Jacques Mansourati,Laurence Jesel,Jean‐Marc Dupuis,Paul Bru,Florence Kyndt,Béatrice Guyomarch,Aurélie Thollet,Nathalie Béhar,Philippe Mabo,Frédéric Sacher,Vincent Probst,Jean‐Baptiste Gourraud
出处
期刊:Heart Rhythm [Elsevier BV]
卷期号:16 (2): 260-267 被引量:30
标识
DOI:10.1016/j.hrthm.2018.08.032
摘要

Studies in Brugada syndrome (BrS) have mainly consisted of men.The purpose of this study was to describe the clinical characteristics and arrhythmic risk factors in BrS women.Consecutive BrS patients were enrolled from 1993 and followed prospectively.Among 1613 patients, 494 were women (mean age 47 ± 16 years). Women were more frequently asymptomatic than men (423 [86%] vs 867 [77%], respectively; P = .001) and less frequently had a spontaneous ECG pattern (107 [22%] vs 398 [36%], respectively; P <.001). During median [25th, 75th percentile] follow-up of 57 [23, 118] vs 62 [22, 113] months (P = .65), arrhythmic events occurred in 12 women (2%) vs 79 men (7%) (P = .0005). Mean age at the first event was 48.6 ± 17.8 years for women vs 43 ± 14.2 years for men (P <.001). Gender was significantly related to cardiac events (hazard ratio [HR] 2.96; 95% confidence interval [CI] 1.6-5.4; P = .0005). In multivariate analysis, event predictors in women were index patient status (HR 10.15; 95% CI 1.7-61.4; P = .01), previous sudden cardiac death (HR 69.4; 95% CI 15-312.5; P <.0001), syncope (HR 6.8; 95% CI 1.4-34.5; P = .02), fragmented QRS (HR 20.2; 95% CI 1.8-228.9; P = .02), and QRS duration >120 ms (HR 4.7; 95% CI 1.2-19.5; P = .03).Women represent a lower-risk group than men among individuals with BrS. In asymptomatic women, fragmented QRS and QRS >120 ms seem to be the only event predictors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
SciGPT应助三新荞采纳,获得10
刚刚
1秒前
1秒前
小杰完成签到 ,获得积分10
2秒前
2秒前
2秒前
万能图书馆应助dd采纳,获得30
3秒前
华仔应助三水采纳,获得10
3秒前
自然卷的春天完成签到,获得积分10
3秒前
zjl900111发布了新的文献求助10
3秒前
kassy完成签到,获得积分10
4秒前
4秒前
4秒前
桐桐应助syx采纳,获得10
4秒前
852应助qu采纳,获得10
5秒前
三新荞发布了新的文献求助10
6秒前
含蓄绿兰发布了新的文献求助10
6秒前
XSY完成签到,获得积分10
6秒前
6秒前
glory_c应助li采纳,获得50
7秒前
7秒前
宥沐完成签到,获得积分10
7秒前
Ttong完成签到,获得积分10
7秒前
7秒前
争气发布了新的文献求助30
7秒前
科目三应助冯富海采纳,获得10
7秒前
8秒前
Cici发布了新的文献求助10
8秒前
恒123完成签到,获得积分10
8秒前
正直的文涛完成签到,获得积分10
8秒前
含糊的寇发布了新的文献求助10
9秒前
9秒前
Lucas应助深情的采波采纳,获得10
9秒前
余烬22发布了新的文献求助10
10秒前
ED应助hggyt采纳,获得10
10秒前
10秒前
TT完成签到,获得积分10
10秒前
HJJHJH发布了新的文献求助30
10秒前
10秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970843
求助须知:如何正确求助?哪些是违规求助? 3515550
关于积分的说明 11178897
捐赠科研通 3250660
什么是DOI,文献DOI怎么找? 1795393
邀请新用户注册赠送积分活动 875828
科研通“疑难数据库(出版商)”最低求助积分说明 805188