动脉瘤
血流动力学
发病机制
医学
心脏病学
内科学
放射科
作者
Sauson Soldozy,Pedro Norat,Mazin Elsarrag,Ajay Chatrath,John S. Costello,Jennifer D. Sokolowski,Petr Tvrdík,M. Yashar S. Kalani,Min S. Park
出处
期刊:Neurosurgical Focus
[Journal of Neurosurgery Publishing Group]
日期:2019-07-01
卷期号:47 (1): E11-E11
被引量:78
标识
DOI:10.3171/2019.4.focus19232
摘要
The pathogenesis of intracranial aneurysms remains complex and multifactorial. While vascular, genetic, and epidemiological factors play a role, nascent aneurysm formation is believed to be induced by hemodynamic forces. Hemodynamic stresses and vascular insults lead to additional aneurysm and vessel remodeling. Advanced imaging techniques allow us to better define the roles of aneurysm and vessel morphology and hemodynamic parameters, such as wall shear stress, oscillatory shear index, and patterns of flow on aneurysm formation, growth, and rupture. While a complete understanding of the interplay between these hemodynamic variables remains elusive, the authors review the efforts that have been made over the past several decades in an attempt to elucidate the physical and biological interactions that govern aneurysm pathophysiology. Furthermore, the current clinical utility of hemodynamics in predicting aneurysm rupture is discussed.
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