羟醛反应
环己酮
化学
磷化氢
有机化学
有机催化
催化作用
对映选择合成
作者
Takashi Mino,Ayaka Omura,Yukari Uda,Kazuya Wakui,Yuri Haga,Masami Sakamoto,Tsutomu Fujita
标识
DOI:10.1016/j.tetasy.2011.11.021
摘要
Chiral phosphine-prolineamide 1a was employed as an organocatalyst in direct asymmetric aldol reactions of various aromatic aldehydes with ketones. Cyclohexanone led to the aldol products in up to 98% ee and with good diastereoselectivity using 10 mol % of TFA and 30 mol % of prolineamide 1a in DMF at 0 °C.
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