磁共振成像
材料科学
磁性纳米粒子
纳米颗粒
纳米技术
放松(心理学)
核磁共振
物理
心理学
医学
社会心理学
放射科
作者
Zijian Zhou,Lijiao Yang,Jinhao Gao,Xiaoyuan Chen
标识
DOI:10.1002/adma.201804567
摘要
Abstract Magnetic nanoparticles (MNPs) have been extensively explored as magnetic resonance imaging (MRI) contrast agents. With the increasing complexity in the structure of modern MNPs, the classical Solomon–Bloembergen–Morgan and the outer‐sphere quantum mechanical theories established on simplistic models have encountered limitations for defining the emergent phenomena of relaxation enhancement in MRI. Recent progress in probing MRI relaxivity of MNPs based on structural features at the molecular and atomic scales is reviewed, namely, the structure–relaxivity relationships, including size, shape, crystal structure, surface modification, and assembled structure. A special emphasis is placed on bridging the gaps between classical simplistic models and modern MNPs with elegant structural complexity. In the pursuit of novel MRI contrast agents, it is hoped that this review will spur the critical thinking for design and engineering of novel MNPs for MRI applications across a broad spectrum of research fields.
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