旁分泌信号
干细胞
间充质干细胞
细胞外小泡
转化研究
移植
细胞生物学
耐受性
生物
人口
医学
癌症研究
生物信息学
生物技术
药理学
内科学
遗传学
不利影响
环境卫生
受体
作者
Jonathan Sheard,Thamil Selvee Ramasamy,Darius Widera
摘要
Mesenchymal stem cells (MSCs) are the most intensely studied type of adult stem cells. Their presence in virtually all vascularised tissues, easy accessibility, good tolerability and safety profile along with the lack of ethical issues has raised a considerable clinical and commercial interest. In this review, we describe the changing views on this cell population and highlight the paradigm shift in its translational use from direct transplantation to the application of MSC-derived paracrine factors with MSCs acting as `Medicinal Signalling Cells` or natural biofactories. Moreover, we summarise current strategies aiming at replacing MSC transplantation with the use of soluble factors and extracellular vesicles secreted by this clinically relevant stem cell type.
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