土曲霉
立体化学
二维核磁共振波谱
麦角甾醇
化学
抗菌剂
烟曲霉
核磁共振谱数据库
曲霉
黑曲霉
生物
植物
有机化学
生物化学
谱线
物理
天文
作者
Abdelaaty Hamed,Ahmed S. Abdel-Razek,Doha A Omran,Mohammad Magdy El-Metwally,Doaa G. El-Hosari,Marcel Frese,Hesham M. A. Soliman,Norbert Sewald,Mohamed Shaaban
标识
DOI:10.1080/14786419.2018.1544977
摘要
Terretonin O (1), a new meroterpenoid, was isolated individually from both methanolic extracts of thermophilic Aspergillus terreus TM8 and marine Aspergillus terreus LGO13. The recently reported terretonins M (2) and N (3) were further isolated from the fungus LGO13 along with nine known compounds, terrelumamide A (4), terrein (5), methyl-3,4,5-trimethoxyl-2-[2-(nicotinamide)benzamido] benzoate (6), butyrolactones I-III (7-9), aspulvinone O (10), ergosterol, ergost-4-ene-3-one and methyl linoleate. Structure of terretonin O (1) was established on the bases of HRESIMS, 1D and 2D NMR spectra and comparison with its analogues in literatures. The relative stereochemistry of 1 was assigned on the basis of NOESY spectra and comparison with reported configuration of its congener compounds 2 and 3. The antimicrobial and cytotoxic activities of the fungal extracts and obtained compounds were assayed using a set of microorganisms, and cervix carcinoma cell line (KB-3-1), respectively. Isolation and taxonomical characterization of the producing strains are reported.
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