铜
氧化应激
氧化还原
细胞凋亡
癌细胞
材料科学
氧化磷酸化
生物物理学
细胞生物学
纳米技术
生物化学
癌症
生物
冶金
遗传学
作者
Junmin Zhang,Dongzhu Duan,Jianqiang Xu,Jianguo Fang
标识
DOI:10.1021/acsami.8b11061
摘要
Transportation of exogenous copper ions into cancer cells by copper carriers has gained increasing interest for cancer chemotherapy. We disclosed herein a redox-dependent copper carrier, 2,2'-dithiodipyridine (DPy), which binds copper ions and carries the cargo into cells. The cellular reducing environment cleaved the disulfide bond in DPy to facilitate unloading copper ions. The elevated copper level then elicits oxidative stress and subsequently promotes the reformation of DPy. Further mechanistic studies revealed that the DPy/copper combination predominantly targets the cellular redox-regulating systems, including the thioredoxin system and the glutathione system, to induce the oxidative stress-mediated death of tumor cells. The discovery of DPy as a cleavable and recyclable copper shuttle provides a proof of concept for designing novel biomaterials for copper transportation as potential anticancer agents.
科研通智能强力驱动
Strongly Powered by AbleSci AI