自愈水凝胶
羧甲基纤维素
肿胀 的
膨胀能力
材料科学
药物输送
化学工程
抗压强度
毒品携带者
傅里叶变换红外光谱
纤维素
复合材料
核化学
化学
高分子化学
纳米技术
钠
冶金
工程类
作者
Daham Jeong,Sang‐Woo Joo,Yiluo Hu,Vijay Vilas Shinde,Eunae Cho,Seunho Jung
标识
DOI:10.1016/j.eurpolymj.2018.05.023
摘要
Carboxymethyl cellulose (CMC)-based hydrogels have superabsorbent properties but low mechanical strength. Variation of other hydrogel components might improve the mechanical strength, but has been occasionally seen to decrease the swelling and drug-loading capacity. To address these problems, we designed a dual-component system, consisting of both carboxymethyl β-cyclodextrin (cmβCD) and CMC. We synthesized the hydrogels by crosslinking βCD or cmβCD with both cellulose (CEL) and CMC to evaluate their intrinsic mechanical strength and swelling capacity. The characteristic structure and morphology of each hydrogel was determined by Fourier- transform infrared spectroscopy, solid-state nuclear magnetic resonance spectroscopy, and field emission scanning electron microscopy. The storage modulus of the cmβCD/CMC gel was nearly eight-fold higher than that of the CMC gel only in rheology tests; the compressive strength was also enhanced while still retaining high swelling ability. We also investigated the drug-loading capacity and subsequent release properties, using tetracycline as a drug model. The cmβCD/CMC hydrogels showed the most effective tetracycline-loading capacity with the highest antibacterial activity among all hydrogels. They also showed the highest mechanical strength and the best drug release properties apart from the appreciable swelling capacity. Furthermore, cmβCD/CMC hydrogels are non-cytotoxic towards human dermal fibroblasts, suggesting their safe use as nontoxic, bio-friendly, and effective drug delivery systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI