SOD1
超氧化物歧化酶
超氧化物
肌萎缩侧索硬化
抗氧化剂
酶
激进的
生物化学
过氧化氢
化学
细胞生物学
生物物理学
生物
医学
病理
疾病
作者
Elis C. A. Eleuthério,Rayne Stfhany Silva Magalhães,Aline de Araújo Brasil,José Raphael Monteiro Neto,Luan de Holanda Paranhos
标识
DOI:10.1016/j.abb.2020.108701
摘要
During cellular respiration, radicals, such as superoxide, are produced, and in a large concentration, they may cause cell damage. To combat this threat, the cell employs the enzyme Cu/Zn Superoxide Dismutase (SOD1), which converts the radical superoxide into molecular oxygen and hydrogen peroxide, through redox reactions. Although this is its main function, recent studies have shown that the SOD1 has other functions that deviates from its original one including activation of nuclear gene transcription or as an RNA binding protein. This comprehensive review looks at the most important aspects of human SOD1 (hSOD1), including the structure, properties, and characteristics as well as transcriptional and post-translational modifications (PTM) that the enzyme can receive and their effects, and its many functions. We also discuss the strategies currently used to analyze it to better understand its participation in diseases linked to hSOD1 including Amyotrophic Lateral Sclerosis (ALS), cancer, and Parkinson.
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