卵清蛋白
免疫学
屋尘螨
哮喘
免疫球蛋白E
过敏原
医学
过敏
螨
抗体
生物
免疫系统
植物
作者
Mei‐Chi Chen,Jesse W. Tai,Cheng-Jang Wu
出处
期刊:Methods in molecular biology
日期:2020-11-24
卷期号:: 101-114
被引量:2
标识
DOI:10.1007/978-1-0716-1001-5_8
摘要
Mouse models of allergic asthma have been utilized to establish the role of T helper type 2 (Th2) cells in driving lung inflammation, airway hyperresponsiveness, and obstruction. Here, we present the allergic asthma models, in which mice are hypersensitized to ovalbumin (OVA) and house dust mite (HDM). These models mimic the major characteristics of human asthma including the eosinophilic inflammation and hyperactivity of the airway, overproduction of Th2 cytokines in the lung, and elevated total and allergen-specific immunoglobulin E (IgE) in serum.
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