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Computational analysis of non-invasive deep brain stimulation based on interfering electric fields

脑深部刺激 神经调节 计算机科学 电场 局部场电位 计算模型 神经科学 轴突 人工神经网络 生物系统 刺激 物理 人工智能 生物 医学 疾病 病理 量子力学 帕金森病
作者
Fariba Karimi,Ahmadreza Attarpour,Rassoul Amirfattahi,Jie Li
出处
期刊:Physics in Medicine and Biology [IOP Publishing]
卷期号:64 (23): 235010-235010 被引量:26
标识
DOI:10.1088/1361-6560/ab5229
摘要

Neuromodulation modalities are used as effective treatments for some brain disorders. Non-invasive deep brain stimulation (NDBS) via temporally interfering electric fields has emerged recently as a non-invasive strategy for electrically stimulating deep regions in the brain. The objective of this study is to provide insight into the fundamental mechanisms of this strategy and assess the potential uses of this method through computational analysis. Analytical and numerical methods are used to compute the electric potential and field distributions generated during NDBS in homogeneous and inhomogeneous models of the brain. The computational results are used for specifying the activated area in the brain (macroscopic approach), and quantifying its relationships to the stimulation parameters. Two automatic algorithms, using artificial neural network (ANN), are developed for the homogeneous model with two and four electrode pairs to estimate stimulation parameters. Additionally, the extracellular potentials are coupled to the compartmental axon cable model to determine the responses of the neurons to the modulated electric field in two developed models and to evaluate the precise activated area location (microscopic approach). Our results show that although the shape of the activated area was different in macroscopic and microscopic approaches, it located only at depth. Our optimization algorithms showed significant accuracy in estimating stimulation parameters. Moreover, it demonstrated that the more the electrode pairs, the more controllable the activated area. Finally, compartmental axon cable modeling results verified that neurons can demodulate and follow the electric field modulation envelope amplitude (MEA) in our models. The results of this study help develop the NDBS method and eliminate some limitations associated with the nonautomated optimization algorithm.
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