抑制因子
生物
拟南芥
茉莉酸
信号转导衔接蛋白
YY1年
心理压抑
互动者
细胞生物学
GATAD2B型
转录调控
转录因子
突变体
基因
发起人
遗传学
信号转导
基因表达
作者
Changjiang Li,Lei Shi,Yanan Wang,Wei Li,Binqing Chen,Lei Zhu,Ying Fu
出处
期刊:Molecular Plant
[Elsevier BV]
日期:2019-11-07
卷期号:13 (2): 246-265
被引量:65
标识
DOI:10.1016/j.molp.2019.10.014
摘要
Suppression mechanisms mediated by transcriptional repressors commonly exist in diverse phytohormone signaling pathways. In Arabidopsis thaliana, JASMONATE-ZIM DOMAIN (JAZ) proteins are transcriptional repressors that function as negative regulators of diverse JA responses. Novel Interactor of JAZ (NINJA) is an adaptor protein connecting JAZs with the co-repressor, TOPLESS (TPL), to mediate gene repression in JA-dependent root growth inhibition and defense pathways. However, whether NINJA or other adaptor proteins are employed in other JA-responsive biological processes remains to be elucidated. In the present study, we demonstrate that a previously uncharacterized protein, ECAP (EAR motif-Containing Adaptor Protein), directly interacts with JAZ6 and JAZ8 and enhances their transcriptional repression activities. We provide evidence that ECAP is a novel adaptor protein for JAZ6/8 recruitment of the transcriptional co-repressor, TOPLESS-RELATED 2 (TPR2), into a transcriptional repressor complex that represses the WD-repeat/bHLH/MYB complex, an important transcriptional activator in the JA-dependent anthocyanin biosynthesis pathway. Our findings, together with previous reports, reveal that specific adaptor proteins play a critical role in distinct JA responses by pairing different JAZs (which possess overlapping but also specific functions) with the general co-repressors, TPL and TPRs.
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