溃疡性结肠炎
脂质信号
炎症性肠病
疾病
炎症
免疫学
免疫
炎症性肠病
医学
克罗恩病
获得性免疫系统
发病机制
免疫系统
病理
作者
Mireille Alhouayek,Hafsa Ameraoui,Giulio G. Muccioli
标识
DOI:10.1016/j.bbalip.2020.158854
摘要
Inflammatory bowel diseases (IBDs), such as Crohn's disease and ulcerative colitis, are lifelong diseases that remain challenging to treat. IBDs are characterized by alterations in intestinal barrier function and dysregulation of the innate and adaptive immunity. An increasing number of lipids are found to be important regulators of inflammation and immunity as well as gut physiology. Therefore, the study of lipid mediators in IBDs is expected to improve our understanding of disease pathogenesis and lead to novel therapeutic opportunities. Here, through selected examples – such as fatty acids, specialized proresolving mediators, lysophospholipids, endocannabinoids, and oxysterols – we discuss how lipid signaling is involved in IBD physiopathology and how modulating lipid signaling pathways could affect IBDs.
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