医学
贝伐单抗
血栓形成
肝素
栓塞
结直肠癌
养生
肺栓塞
外科
化疗
癌症
麻醉
内科学
作者
Shotaro Korehisa,Akira Kabashima,Sho Nambara,Kiminori Watanabe,Kenji Umeda,Hidenori Koso,Kouichiro Tahara,Yusuke Nakamura,Hideaki Anai
出处
期刊:PubMed
日期:2020-06-01
卷期号:47 (6): 989-992
被引量:1
摘要
A 61-year-old man underwent CapeOX plus bevacizumab chemotherapyafter right hemicolectomyfor metastatic ascending colon cancer. On the 7th dayafter the first administration, he had sudden abdominal pain and nausea. Contrast-enhanced computed tomographyrevealed aortic thrombosis and a superior mesenteric artery(SMA)embolism that was considered to be associated with bevacizumab. Bevacizumab was discontinued and anticoagulation therapyusing heparin and urokinase was performed. Brain infarction of the left middle cerebral arteryoccurred on the 15th dayafter the first administration and thrombectomywas performed. Anticoagulation therapyusing heparin, bayaspirin, and edoxaban tosilate hydrate was performed. The aortic thrombosis and SMA embolism resolved with treatment, but the patient died following an increase in peritoneal dissemination. It should be noted that unexpectedlysevere aortic thrombosis occurred during the first administration of CapeOX plus bevacizumab for metastatic colon cancer.
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