[The disease burden of pancreatic cancer in China in 1990 and 2017].

Objective: To analyze the disease burden of pancreatic cancer in China in 1990 and 2017. Methods: Province-specific data in China from the Global Burden of Disease Study (GBD) 2017 were used to describe the change of death status, disease burden of pancreatic cancer in Chinese population by specific province and age groups, including incidence, mortality, disability-adjusted life years (DALY), years of life lost (YLL) due to premature mortality and years lived with disability (YLD) in 1990 and 2017. Meanwhile the incidence, mortality, DALY rate, YLL rate, YLD rate were standardized by the GBD global standard population in 2017. Results: In 2017, the new cases of pancreatic cancer, incidence and age-standardized incidence accounted for 83.6 thousand, 5.92/100 000 and 4.37/100 000 in China, with an increase of 230.94%, 180.45% and 49.88% compared with 1990, respectively. The total number of deaths, mortality and age-standardized mortality appeared as 85.1 thousand, 6.02/100 000, 4.48/100 000, with an increase of 236.08%, 184.80% and 47.51% respectively. The incidence and mortality of pancreatic cancer increased with age and accelerated from the age of 55 to 59 both in 1990 and 2017. The highest incidence and mortality showed in 85-89 years old in 2017 and in 90-94 years old in 1990. The standardized DALY rate of pancreatic cancer increased from 71.00/100 000 in 1990 to 94.32/100 000 in 2017, increased by 32.84%. The standardized YLL rate increased from 70.39/100 000 to 93.42/100 000, increased by 32.72%. The standardized YLD rate increased from 0.62/100 000 to 0.90/100 000, increased by 45.80%. In terms of age distribution, DALY rate, YLL rate and YLD rate of pancreatic cancer basically showed an increasing trend with age in 1990 and 2017. In 2017, Jiangsu (7.61/100 000), Shanghai (7.52/100 000) and Liaoning (6.84/100 000) ranked the top three provinces in terms of standardized mortality. Compared with 1990, Henan (104.28%), Sichuan (94.02%) and Hebei (90.39%) saw the fastest increase in standardized mortality. Conclusions: The incidence, mortality and disease burden of pancreatic cancer in China increased significantly from 1990 to 2017. Prevention and control measures should be strengthened to reduce the disease burden of pancreatic cancer.目的： 分析1990年与2017年中国胰腺癌的发病、死亡和疾病负担及其变化情况。 方法： 利用2017年全球疾病负担研究结果，描述1990年与2017年我国胰腺癌的发病、死亡、伤残调整寿命年（DALY）、过早死亡损失寿命年（YLL）和伤残损失寿命年（YLD）在总人群、各年龄组的分布及变化情况，并以全球疾病负担研究世界标准人口计算标化率。 结果： 2017年中国胰腺癌发病人数为8.36万，发病率为5.92/10万，标化发病率为4.37/10万，较1990年分别增长230.94%、180.45%和49.88%；2017年死亡人数8.51万，死亡率为6.02/10万，标化死亡率为4.48/10万，较1990年分别上升236.08%、184.80%和47.51%。1990年与2017年胰腺癌发病率、死亡率均有随年龄增长而增大的趋势，2017年85~89岁年龄组发病率、死亡率最高，1990年90~94岁年龄组发病率、死亡率最高。胰腺癌标化DALY率由1990年的71.00/10万增长到2017年的94.32/10万，增长率为32.84%；标化YLL率由70.39/10万增长到93.42/10万，增长率为32.72%；标化YLD率由0.62/10万增长到0.90/10万，增长率为45.80%。从年龄分布来看，1990年与2017年胰腺癌DALY率、YLL率和YLD率随年龄增长基本呈上升趋势。2017年胰腺癌标化死亡率排名前三的省份分别是江苏（7.61/10万）、上海（7.52/10万）和辽宁（6.84/10万），相比1990年，标化死亡率增长率最高的3个省份分别为河南（104.28%）、四川（94.02%）、河北（90.39%）。 结论： 我国胰腺癌的疾病负担在1990－2017年间有较大增长，需加强防治措施。.