医学
肝硬化
肝纤维化
细胞外基质
肝纤维化
纤维化
慢性肝病
药物开发
病理
药品
内科学
药理学
生物
细胞生物学
标识
DOI:10.1111/1751-2980.12854
摘要
Hepatic fibrosis is a reparative response of diffuse over‐deposition and abnormal distribution of extracellular matrix (collagen, glycoprotein and proteoglycans) after exposure to various kinds of liver injuries, and is a key step in the developmental process of various chronic liver diseases leading to cirrhosis. Recently, many advances in our understanding of hepatic fibrosis have been obtained through basic and clinical research. Therefore, this consensus summarizes and offers 15 evidence‐based recommendations on the diagnosis and evaluation of hepatic fibrosis, its treatment, drug development and applications.
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