In article number 1900390, Richard J. Williams, David R. Nisbet, and co-workers report on a peptide hydrogel programmed for the minimally invasive transplantation of stem cells. The cell-laden droplets formed by the hydrogel protect cells during syringe administration. The hydrogel then ‘switches’ to offer long-term bioactive support. These insights will have a significant impact for tissue repair, biofabrication, drugs, and cellinstructive 3D cultures.