The combined effects of cardiac geometry, microcirculation, and tissue characteristics on cardiac systolic and diastolic function in subclinical diabetes mellitus-related cardiomyopathy

医学 心脏病学 内科学 糖尿病性心肌病 舒张期 糖尿病 灌注 微循环 亚临床感染 心脏磁共振成像 心肌病 心功能曲线 心力衰竭 磁共振成像 血压 放射科 内分泌学
作者
Jiang Li,Jin Wang,Xi Liu,Zhenlin Li,Chunchao Xia,Linjun Xie,Yue Gao,Mengting Shen,Pei‐Lun Han,Yingkun Guo,Zhi‐gang Yang
出处
期刊:International Journal of Cardiology [Elsevier BV]
卷期号:320: 112-118 被引量:25
标识
DOI:10.1016/j.ijcard.2020.07.013
摘要

BackgroundDiabetes mellitus-related cardiomyopathy has recently been described as a distinct progression of left ventricular (LV) systolic and diastolic dysfunction. Pathological changes in the myocardium may explain the development of two different phenotypes. We evaluated the effects of LV geometry, myocardial microcirculation, and tissue characteristics on cardiac deformation in patients with subclinical type 2 diabetes mellitus (T2DM) utilizing multiparametric cardiac magnetic resonance (CMR) imaging.MethodsA total of 135 T2DM patients and 55 matched controls were prospectively enrolled and performed multiparametric CMR examination. CMR-derived parameters including cardiac geometry, function, microvascular perfusion, T1 mapping, T2 mapping, and strain were analyzed and compared between T2DM patients and controls.ResultsThe univariable and multivariable analysis of systolic and diastolic function revealed that longer duration of diabetes was associated with decreased longitudinal peak systolic strain rate (PSSR-L) (β = 0.195, p = .013), and higher remodeling index and higher extracellular volume (ECV) tended to correlate with decreased longitudinal peak diastolic strain rate (PDSR-L) (remodeling index, β = −0.339, p = .000; ECV, β = −0.172, p = .026), whereas microvascular perfusion index and T2 value affected both PSSR-L (perfusion index, β = −0.328, p = .000; T2 value, β = 0.306, p = .000) and PDSR-L (perfusion index, β = 0.209, p = .004; T2 value, β = −0.275, p = .000) simultaneously.ConclusionsThe LV concentric remodeling and myocardial fibrosis correlated with diastolic function, and perfusion function and myocardial edema were associated with both LV systolic and diastolic function.
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