体内
荧光
纳米材料
秀丽隐杆线虫
生物相容性材料
临床前影像学
化学
量子点
纳米技术
平衡/c
纳米颗粒
生物物理学
材料科学
生物医学工程
生物化学
生物
免疫学
生物技术
医学
免疫系统
基因
物理
量子力学
作者
Kundan Singh Rawat,Shachi Mishra,Tanvi Baghel,Soobiya Fatima,Aijaz Ahmad John,Navodayam Kalleti,Divya Singh,Aamir Nazir,Srikanta Kumar Rath,Atul Goel
摘要
Luminescent carbon quantum dots (CQDs) prepared from aqueous beetroot extract were developed as unique fluorescent nanomaterials for in vivo live animal imaging applications. Blue (B) and green (G) emitting environmentally benign CQDs (particle size of 5 nm and 8 nm, respectively) exhibited bright fluorescence in aqueous medium and were found to be biocompatible, photostable and non-toxic in animal models. The in vivo imaging and toxicity evaluation of both CQDs were performed for the first time in the Caenorhabditis elegans (C. elegans) model, which revealed consistent fluorescence in the gut tissues of the worms without exerting any sign of toxic effects on the nematodes. The in vivo bio-distribution of G-CQDs given by tail vein injection in live BALB/c mice showed optical signals in the lower abdominal regions, mainly in the intestine, and cleared from the body through faeces. The tremendous potential shown by these eco-friendly CQDs in the C. elegans and mice models advocates new hopes for greener CQD nanomaterials as diagnostic tools in the biomedical field.
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