G蛋白偶联受体
异三聚体G蛋白
视紫红质
逮捕
G蛋白
信号转导
细胞生物学
受体
生物
G蛋白偶联受体激酶
化学
计算生物学
生物化学
视网膜
作者
Jingjing Wang,Tian Hua,Zhi‐Jie Liu
标识
DOI:10.1016/j.sbi.2020.04.008
摘要
G protein-coupled receptors (GPCRs) couple to diverse heterotrimeric G protein subtypes and then activate downstream signaling pathways in classical GPCR activation. It has also been found that GPCRs transduce signals through different regulatory proteins, such as arrestins. Recently, owing to the breakthroughs in cryo-electron macroscopy (Cryo-EM), numerous structures of GPCR-G protein or GPCR-arrestin complexes have been deciphered. In this review, we summarize most of reported GPCR signaling complex structures, with an emphasis on the structural features of rhodopsin-like GPCR activation and G protein-binding/arrestin-binding modes, to illustrate the activation and signaling mechanism of rhodopsin-like GPCRs.
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