Multiple linear regression analysis of modified Kupperman index score in newly diagnosed patients with early ovarian failure and the age of diagnosis and quality of life

Objective To analyze the correlation between menopausal symptoms of newly diagnosed patients with premature ovarian failure (POF) and age of diagnosis and quality of life in all dimensions. Methods A cross-sectional study was used. The modified Kupperman index and quality of life scale (Short Form 36 Health Survey Profile, SF-36) were used to assess the patients with POF who were treated for the first time in the Gynecologic Endocrine Outpatient Clinics of Women’s Hospital, Zhejiang University School of Medicine from January 2015 to December 2018. The correlation was analyzed by the multiple linear regression analysis method. Results A total of 170 patients completed the survey, among which 122 women (71.76%) had menopausal symptoms. The age of diagnosis for patients with menopausal symptoms [(34.9±5.1) years] was older than that for patients without symptoms [(32.7±6.2) years, P=0.042]. Except the physiological function domain, POF patients with menopausal symptoms had impaired quality of life in domains of role-physiological (P=0.006), bodily pain (P=0.025), general health (P<0.000 1), vitality (P<0.000 1), social functioning (P=0.006), role-emotional (P=0.004) and mental health (P=0.005) compared with patients with no symptom. The results of multiple linear regression analysis showed that the diagnosed age, scores of general health, role-emotional, and vitality of POF patients were correlated with the total scores of modified Kupperman index, with regression coefficients of 0.158, -0.219, -0.222 and -0.226, respectively (P<0.05 for all). Conclusion The life quality of POF patients with menopausal symptoms was significantly impaired. The age of diagnosis, quality of life in dimensions of general health, role-emotional and vitality were correlated with the occurrence of menopausal symptoms. Key words: Premature ovarian failure; Primary ovarian insufficiency; Menopausal symptom; Quality of life; Multiple linear regression