Research progress in norovirus virus-like particle vaccine

Norovirus (NoV) is a common pathogen causing acute gastroenteritis. According to WHO statistics, more than 100 million people are infected with NoV every year, and severe infections can lead to death. Therefore, the development of NoV vaccine is urgent. At present, the research of NoV vaccine is mainly focused on virus-like particle (VLP) vaccine. In this review, the main challenges in the development of NoV vaccine and research status of NoV VLP vaccine are introduced, based on the biological and epidemiological characteristics of NoV. Key words: Norovirus; Virus-like particle; Vaccines, subunit