作者
Wei-Shu Xue,Yafen Wei,Ningyao Wang,Nan Wang,Guohui Xu,Yue-Fen Ying
摘要
Objective
To investigate the correlation between apolipoprotein and homocysteine levels with the stability of carotid plaque and the degree of stenosis.
Methods
One hundred elderly patients with acute cerebral infarction from January 2017 to December 2017 were collected continuously in Harbin Fourth Hospital, All patients underwent color Doppler ultrasound examination of carotid artery.They were divided into stable plaque group and unstable plaque group according to the results of color Doppler ultrasound, then according to the degree of stenosis they were divided into intimal thickening group with 23 cases, mild stenosis (stenosis degree<50%) with 26 cases, moderate stenosis group (50%≤stenosis degree<70%) with 28 cases, severe stenosis group (70%≤stenosis degree) with 23 cases.All the patients were selected to collect the blood of the elbow in the early morning to detect the level of apolipoprotein B and Hcy.
Results
Compared with unstable plaque group, smoking, drinking, hemoglobin A1c (HbA1c), ApoB and Hcy had significant differences (all P 0.05). Multivariate logistic regression was performed after correcting the related risk factors excluding blood lipids.The results showed that alcohol (OR=1.247(95%CI: 0.626-1.958), P=0.043), Hcy (OR=3.163(95%CI: 1.824-4.772), P=0.045), bloodpressure (OR=1.286(95%CI: 0.688-2.005), P=0.027), HbA1c (OR=3.671(95%CI: 1.904-6.630), P=0.011), ApoB (OR=1.717(95%CI: 1.005-2.634), P=0.036), LDL-C(OR=1.516(95%CI: 0.968-2.489), P=0.024), TC(OR=1.403(95%CI: 0.801-2.343), P=0.030) and TG (OR=1.342(95%CI: 0.712-2.198), P=0.019) are independent risk factors for unstablecarotid plaque and severe carotid stenosis.
Conclusion
Apolipoprotein and homocysteine may be independent predictors of unstable carotid plaque and severity of carotid stenosis.
Key words:
Apolipoprotein; Homocysteine; Carotid atherosclerotic plaque