Study on the Correlation between apolipoprotein and homocysteine levels with carotid atherosclerotic plaque stability and degree of stenosis

医学 狭窄 同型半胱氨酸 内科学 载脂蛋白B 心脏病学 超声波 逻辑回归 放射科 胆固醇
作者
Wei-Shu Xue,Yafen Wei,Ningyao Wang,Nan Wang,Guohui Xu,Yue-Fen Ying
出处
期刊:Clinical Medicine of China [Chinese Medical Association]
卷期号:35 (4): 354-358
标识
DOI:10.3760/cma.j.issn.1008-6315.2019.04.014
摘要

Objective To investigate the correlation between apolipoprotein and homocysteine levels with the stability of carotid plaque and the degree of stenosis. Methods One hundred elderly patients with acute cerebral infarction from January 2017 to December 2017 were collected continuously in Harbin Fourth Hospital, All patients underwent color Doppler ultrasound examination of carotid artery.They were divided into stable plaque group and unstable plaque group according to the results of color Doppler ultrasound, then according to the degree of stenosis they were divided into intimal thickening group with 23 cases, mild stenosis (stenosis degree<50%) with 26 cases, moderate stenosis group (50%≤stenosis degree<70%) with 28 cases, severe stenosis group (70%≤stenosis degree) with 23 cases.All the patients were selected to collect the blood of the elbow in the early morning to detect the level of apolipoprotein B and Hcy. Results Compared with unstable plaque group, smoking, drinking, hemoglobin A1c (HbA1c), ApoB and Hcy had significant differences (all P 0.05). Multivariate logistic regression was performed after correcting the related risk factors excluding blood lipids.The results showed that alcohol (OR=1.247(95%CI: 0.626-1.958), P=0.043), Hcy (OR=3.163(95%CI: 1.824-4.772), P=0.045), bloodpressure (OR=1.286(95%CI: 0.688-2.005), P=0.027), HbA1c (OR=3.671(95%CI: 1.904-6.630), P=0.011), ApoB (OR=1.717(95%CI: 1.005-2.634), P=0.036), LDL-C(OR=1.516(95%CI: 0.968-2.489), P=0.024), TC(OR=1.403(95%CI: 0.801-2.343), P=0.030) and TG (OR=1.342(95%CI: 0.712-2.198), P=0.019) are independent risk factors for unstablecarotid plaque and severe carotid stenosis. Conclusion Apolipoprotein and homocysteine may be independent predictors of unstable carotid plaque and severity of carotid stenosis. Key words: Apolipoprotein; Homocysteine; Carotid atherosclerotic plaque

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