癌变
激酶
丝氨酸
生物
癌症研究
癌症
细胞生长
磷酸化
信号转导
苏氨酸
蛋白激酶A
细胞生物学
生物化学
遗传学
作者
Karthik Thangaraj,Lavanya Ponnusamy,Sathan Raj Natarajan,Ravi Manoharan
标识
DOI:10.1016/j.drudis.2020.09.029
摘要
Maternal embryonic leucine zipper kinase (MELK)/Murine protein serine-threonine kinase 38 (MPK38) is a member of the AMP-related serine-threonine kinase family, which has been reported to be involved in the regulation of many cellular events, including cell proliferation, apoptosis, and metabolism, partly by phosphorylation and regulation of several signaling molecules. The abnormal expression of MELK has been associated with tumorigenesis and malignant progression in various types of cancer. Currently, several small-molecule inhibitors of MELK are under investigation although only OTS167 has entered clinical trials. In this review, we elaborate on the relative contributions of MELK pathways in the physiological process, their oncogenic role in carcinogenesis, and targeted agents under development for the treatment of cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI