卡巴胆碱
内科学
医学
异丙肾上腺素
大麻酚
心室
内分泌学
收缩
心脏病学
受体
刺激
精神科
大麻
作者
Anna Pędzińska‐Betiuk,Jolanta Weresa,Eberhard Schlicker,Ewa Harasim‐Symbor,Marek Toczek,Irena Kasacka,Bernadetta Gajo,Barbara Malinowska
标识
DOI:10.1016/j.taap.2020.115368
摘要
Cannabidiol (CBD) is suggested to possess cardioprotective properties. We examined the influence of chronic (10 mg/kg once daily for 2 weeks) CBD administration on heart structure (e.g. cardiomyocyte width) and function (e.g. stimulatory and inhibitory responses induced by β-adrenoceptor (isoprenaline) and muscarinic receptor (carbachol) activation, respectively). Experiments were performed on hearts and/or left atria isolated from spontaneously (SHR) and deoxycorticosterone (DOCA-salt) hypertensive rats; Wistar-Kyoto (WKY) and sham-operated rats (SHAM) served as the respective normotensive controls. CBD diminished the width of cardiomyocytes in left ventricle and reduced the carbachol-induced vasoconstriction of coronary arteries both in DOCA-salt and SHR. However, it failed to affect left ventricular hypertrophy and even aggravated the impaired positive and negative lusitropic effects elicited by isoprenaline and carbachol, respectively. In normotensive hearts CBD led to untoward structural and functional effects, which occurred only in WKY or SHAM or, like the decrease in β1-adrenoceptor density, in either control strain. In conclusion, due to its modest beneficial effect in hypertension and its adverse effects in normotensive hearts, caution should be taken when using CBD as a drug in therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI