指数富集配体系统进化
适体
选择(遗传算法)
计算生物学
生物
指数函数
核糖核酸
纳米技术
生物系统
计算机科学
材料科学
遗传学
数学
人工智能
基因
数学分析
作者
Kimberly Stewart,Weihong Tan,Jong Y. Park
标识
DOI:10.1007/978-1-4939-9769-5_15
摘要
Cell-SELEX is a live cell-based in vitro selection method that generates functional oligonucleotides, or aptamers. Often referenced as the chemist's antibody, aptamers bind to select targets with high affinity and can be utilized in a number of applications, including biomedicine, bioimaging, and biosensing. Here we describe the cell-SELEX technique and discuss this methodology's unique merit(s)-namely the ability to isolate highly selective aptamer panels with no prior knowledge of cellular signatures. This strategy thus presents as a technology that has the potential to enhance the precision of molecular medicine and targeted therapeutics.
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