生发中心
背景(考古学)
淋巴系统
医学
淋巴
混淆
癌症
病理
内科学
生物
免疫学
B细胞
抗体
古生物学
作者
Luis Munoz‐Erazo,Janet L Rhodes,Valentine Marion,Roslyn A. Kemp
标识
DOI:10.1038/s41423-020-0457-0
摘要
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within nonlymphoid tissue. They share structural and functional characteristics with secondary lymphoid structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell region. TLS have been described in several types of cancers and are usually associated with positive patient outcomes. However, TLS differ vastly in cellular composition and location within tissue types. In this review, we discuss factors confounding the interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors in the context of translation to regular clinical use.
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