Danhong injection A modulator for Golgi structural stability after cerebral ischemia- reperfusion injury

The cerebral ischemia-reperfusion model was established using the suture occlusion method,and rats were intraperitoneally given 8 mL/kg Danhong injection once a day prior to mode establishment.Rat brain tissues were harvested at 6,24,48,72 hours after reperfusion Immunohistochemical staining showed that transforming growth factor-β1 expression increased while Golgi matrix protein GM130 expression decreased after cerebral ischemia-reperfusion Danhong injection was shown to significantly up-regulate the expression of transforming growth factor-β1 and GM130,and expression levels peaked at 7 days after reperfusion.At 7 days after cerebral ischemia-reperfusion,Golgi morphology was damaged in untreated rats,while Golg morphology breakage was not observed after intervention with Danhong injection.These experimental findings indicate that Danhong injection can up-regulate the expression of transforming growth factor-β1 and GM130,and maintain Golgi stability,thus playing a neuroprotective role in rats after cerebral ischemia-reperfusion.