免疫系统
肠道菌群
生物
肠-脑轴
大脑发育
脑损伤
免疫学
神经科学
作者
David Seki,Margit Mayer,Bela Hausmann,Petra Pjevac,Vito Giordano,Katharina Goeral,Lukas Unterasinger,Katrin Klebermaß-Schrehof,Kim De Paepe,Tom Van de Wiele,Andreas Spittler,Gregor Kasprian,Benedikt Warth,Angelika Berger,David Berry,Lukas Wisgrill
标识
DOI:10.1016/j.chom.2021.08.004
摘要
Premature infants are at substantial risk for suffering from perinatal white matter injury. Though the gut microbiota has been implicated in early-life development, a detailed understanding of the gut-microbiota-immune-brain axis in premature neonates is lacking. Here, we profiled the gut microbiota, immunological, and neurophysiological development of 60 extremely premature infants, which received standard hospital care including antibiotics and probiotics. We found that maturation of electrocortical activity is suppressed in infants with severe brain damage. This is accompanied by elevated γδ T cell levels and increased T cell secretion of vascular endothelial growth factor and reduced secretion of neuroprotectants. Notably, Klebsiella overgrowth in the gut is highly predictive for brain damage and is associated with a pro-inflammatory immunological tone. These results suggest that aberrant development of the gut-microbiota-immune-brain axis may drive or exacerbate brain injury in extremely premature neonates and represents a promising target for novel intervention strategies.
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