In order to improve the rapidity and real-time of infrared image generation, and make the user and computer have a good interaction, the method of developing virtual reality simulation system based on Vega Prime environment is introduced. The 3D model of target is established by Creator software, and the infrared and atmosphere are modeled by TMM and mat tools of Vega Prime. At the same time, the attenuation effect of atmosphere on infrared radiation is considered. The infrared image is simulated with Ondulus IR software module of Vega Prime. Ondulus IR is a new simulation module, which is based on the accurate infrared radiation principle for modeling and real-time simulation, and real-time rendering to generate infrared images. When using Creator to model, the principle is to reduce the number of polygons as much as possible. The completed model needs to be simplified by deleting polygons and merging faces, which improves the realtime and speed while maintaining the characteristics of the model. Based on VC + + 6.0 integrated development environment, combined with the development characteristics of MFC application program, this paper analyzes the development environment of Vega Prime software, realizes the simulation process and outputs the results of infrared image simulation, which has certain practicability in the development and implementation of infrared visual simulation.