Lower plasma total tau in adolescent psychosis: Involvement of the orbitofrontal cortex

精神病 眶额皮质 心理学 抗精神病药 精神分裂症(面向对象编程) 内科学 精神科 内分泌学 神经科学 医学 前额叶皮质 认知
作者
Dimitrios Andreou,Kjetil Nordbø Jørgensen,Stener Nerland,Runar Smelror,Kirsten Wedervang-Resell,Cecilie Haggag Johannessen,Anne Margrethe Myhre,Ole A. Andreassen,Kaj Blennow,Henrik Zetterberg,Ingrid Agartz
出处
期刊:Journal of Psychiatric Research [Elsevier BV]
卷期号:144: 255-261 被引量:1
标识
DOI:10.1016/j.jpsychires.2021.10.031
摘要

Schizophrenia is thought to be a neurodevelopmental disorder with neuronal migration, differentiation and maturation disturbances. Tau is a microtubule-associated protein with a crucial role in these processes. Lower circulating tau levels have been reported in adults with schizophrenia, but this association has not been investigated in adolescent psychosis. We aimed to test the hypotheses that a) adolescents with early-onset psychosis (EOP; age of onset <18 years) display lower plasma tau concentrations compared to healthy controls, and b) among patients with psychosis, tau levels are linked to structural brain measures associated with the microtubule-associated tau (MAPT) gene and psychosis. We included 37 adolescent patients with EOP (mean age 16.4 years) and 59 adolescent healthy controls (mean age 16.2 years). We investigated putative patient-control differences in plasma total tau concentrations measured by a Single molecule array (Simoa) immunoassay. We explored the correlations between tau and selected structural brain measures based on T1-weighted MRI scans processed in FreeSurfer v6.0. We found significantly lower plasma tau concentrations in patients compared to healthy controls (p = 0.017, partial eta-squared = 0.061). Tau was not associated with antipsychotic use or the antipsychotic dosage. Among patients but not healthy controls, tau levels were positively correlated with the cortical orbitofrontal surface area (p = 0.013, R-squared = 0.24). The results are suggestive of a tau-related neurodevelopmental disturbance in adolescent psychosis.
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