Comparative analysis of hippocampal transcriptional features between major depressive disorder patients and animal models

海马结构 重性抑郁障碍 神经科学 动物模型 心理学 医学 精神科 内科学 认知
作者
Siwen Gui,Yiyun Liu,Juncai Pu,Xuemian Song,Xiaopeng Chen,Weiyi Chen,Xiaogang Zhong,Haiyang Wang,Lanxiang Liu,Peng Xie
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:293: 19-28 被引量:10
标识
DOI:10.1016/j.jad.2021.06.007
摘要

Major depressive disorder (MDD) is a psychiatric disorder caused by various etiologies. Chronic stress models are used to simulate the heterogeneous pathogenic processes of depression. However, few studies have compared transcriptional features between stress models and MDD patients.We generated hippocampal transcriptional profiles of the chronic social defeat model by RNA sequencing and downloaded raw data of the same brain region from public databases of the chronic unpredictable mild stress model, the learned helplessness model, and MDD patients. Differential expression and gene co-expression analyses were integrated to compare transcriptional features between stress models and MDD patients.Each stress model shared 11.4% to 16.3% of differentially expressed genes with MDD patients. Functional analysis at the gene expression level identified altered ensheathment of neurons in both stress models and MDD patients. At the gene network level, each stress model shared 20.9% to 41.6% of co-expressed genes with MDD patients. Functional analysis based on these genes found that axon guidance signaling is the most significantly enriched pathway that was shared by all stress models and MDD patients.This study was limited by considering only a single brain region and a single sex of stress model animals.Our results show that hippocampal transcriptional features of stress models partially overlap with those of MDD patients. The canonical pathways of MDD patients, including ensheathment of neurons, PTEN signaling, and axonal guidance signaling, were shared with all stress models. Our findings provide further clues to understand the molecular mechanisms of depression.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
默存完成签到,获得积分10
1秒前
风中的金鱼完成签到 ,获得积分10
3秒前
橙汁完成签到,获得积分10
4秒前
普鲁卡因发布了新的文献求助10
7秒前
cora完成签到 ,获得积分10
13秒前
徐伟康完成签到 ,获得积分10
13秒前
Minicoper完成签到,获得积分10
24秒前
科研通AI5应助普鲁卡因采纳,获得10
24秒前
111完成签到 ,获得积分10
24秒前
奥特曼完成签到 ,获得积分10
24秒前
苏苏完成签到,获得积分10
25秒前
大橙子完成签到,获得积分10
25秒前
kelite完成签到 ,获得积分10
26秒前
火星上的雨柏完成签到 ,获得积分10
27秒前
JY完成签到,获得积分10
28秒前
知行合一完成签到 ,获得积分10
28秒前
31秒前
31秒前
笑林完成签到 ,获得积分10
32秒前
wwl完成签到,获得积分10
32秒前
娟娟完成签到 ,获得积分10
33秒前
Hollen完成签到 ,获得积分10
33秒前
janejane发布了新的文献求助10
34秒前
35秒前
32429606完成签到 ,获得积分10
35秒前
36秒前
普鲁卡因发布了新的文献求助10
38秒前
发个15分的完成签到 ,获得积分10
40秒前
40秒前
wellyou发布了新的文献求助10
40秒前
量子星尘发布了新的文献求助10
45秒前
自由的鹏涛完成签到,获得积分20
48秒前
49秒前
在水一方应助Nayvue采纳,获得10
49秒前
52秒前
Ryan完成签到,获得积分10
53秒前
General完成签到 ,获得积分10
53秒前
谦让汝燕完成签到,获得积分10
55秒前
wellyou完成签到,获得积分10
56秒前
mint完成签到,获得积分10
58秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038128
求助须知:如何正确求助?哪些是违规求助? 3575831
关于积分的说明 11373827
捐赠科研通 3305610
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022