细胞内
药物输送
纳米技术
化学
非阻塞I/O
光电化学
生物物理学
调色板(绘画)
材料科学
电化学
计算机科学
生物化学
催化作用
电极
物理化学
生物
操作系统
作者
Yi‐Fan Ruan,Feng‐Zao Chen,Yi‐Tong Xu,Tian‐Yang Zhang,Si‐Yuan Yu,Weiwei Zhao,Dechen Jiang,Hong‐Yuan Chen,Jing‐Juan Xu
标识
DOI:10.1002/anie.202111608
摘要
With reduced background and high sensitivity, photoelectrochemistry (PEC) may be applied as an intracellular nanotool and open a new technological direction of single-cell study. Nevertheless, the present palette of single-cell tools lacks such a PEC-oriented solution. Here a dual-functional photocathodic single-cell nanotool capable of direct electroosmotic intracellular drug delivery and evaluation of oxidative stress is devised by engineering a target-specific organic molecule/NiO/Ni film at the tip of a nanopipette. Specifically, the organic molecule probe serves simultaneously as the biorecognition element and sensitizer to synergize with p-type NiO. Upon intracellular delivery at picoliter level, the oxidative stress effect will cause structural change of the organic probe, switching its optical absorption and altering the cathodic response. This work has revealed the potential of PEC single-cell nanotool and extended the boundary of current single-cell electroanalysis.
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