心肌梗塞
医学
血管生成
生物医学工程
治疗性血管生成
心功能曲线
渗透(HVAC)
心脏病学
内科学
心力衰竭
新生血管
材料科学
复合材料
作者
Shixing Huang,Dong Lei,Qi Yang,Yang Yang,Chenyu Jiang,Hongpeng Shi,Bei Qian,Qiang Long,Wenyi Chen,Youming Chen,Lan Zhu,Wenjie Yang,Li Wang,Wangxi Hai,Qiang Zhao,Zhengwei You,Xiaofeng Ye
出处
期刊:Nature Medicine
[Springer Nature]
日期:2021-03-01
卷期号:27 (3): 480-490
被引量:76
标识
DOI:10.1038/s41591-021-01279-9
摘要
Despite advances in technologies for cardiac repair after myocardial infarction (MI), new integrated therapeutic approaches still need to be developed. In this study, we designed a perfusable, multifunctional epicardial device (PerMed) consisting of a biodegradable elastic patch (BEP), permeable hierarchical microchannel networks (PHMs) and a system to enable delivery of therapeutic agents from a subcutaneously implanted pump. After its implantation into the epicardium, the BEP is designed to provide mechanical cues for ventricular remodeling, and the PHMs are designed to facilitate angiogenesis and allow for infiltration of reparative cells. In a rat model of MI, implantation of the PerMed improved ventricular function. When connected to a pump, the PerMed enabled targeted, sustained and stable release of platelet-derived growth factor-BB, amplifying the efficacy of cardiac repair as compared to the device without a pump. We also demonstrated the feasibility of minimally invasive surgical PerMed implantation in pigs, demonstrating its promise for clinical translation to treat heart disease. Implantation of a perfusable device into the epicardium enables delivery of therapeutic agents and infiltration of reparative cells into the heart, amplifying the therapeutic effects of FGF-23 in a rat model of myocardial infarction.
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