肝细胞癌
医学
肝硬化
微泡
接收机工作特性
诊断生物标志物
外体
癌
生物标志物
慢性肝炎
小RNA
曲线下面积
内科学
癌症研究
肿瘤科
病理
诊断准确性
基因
免疫学
生物
病毒
药代动力学
生物化学
作者
Lihua Lyu,Wenjing Yang,Jiayi Yao,Hao Wang,Jie Zhu,Anli Jin,Te Liu,Beili Wang,Jian Zhou,Jia Fan,Xin‐Rong Yang,Wei Guo
出处
期刊:Biomarkers in Medicine
[Future Medicine]
日期:2021-03-05
卷期号:15 (5): 359-371
被引量:34
标识
DOI:10.2217/bmm-2020-0476
摘要
Aim: We aimed to identify novel exosomal circular RNAs for hepatocellular carcinoma (HCC) diagnosis. Materials & methods: Exosomes were extracted and characterized. The expression level of exosomal circRNAs were verified via quantitative real-time PCR. The diagnostic value of candidate circRNAs was evaluated according to the receiver operating characteristic curve analysis. Results: The exosomal circ_0070396 significantly elevated in HCC patients than other control groups and it performed better in distinguishing HCC patients from healthy donors than that of α-fetoprotein. Combination of two above markers exerted greater diagnostic performance. Exosomal circ_0070396 could discriminate HCC individuals from patients with chronic hepatitis B and liver cirrhosis. Intriguingly, exosomal circ_0070396 was positively correlated with HCC progression. Conclusion: Exosomal circ_0070396 may be a potential biomarker for HCC detection and management.
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