脉动流
血流动力学
升主动脉
心脏病学
主动脉
血流
主动脉弓
剪应力
流入
内科学
心力衰竭
医学
材料科学
生物医学工程
机械
物理
复合材料
作者
Ying Chen,Yunmei Yang,Wenchang Tan,Liqin Fu,Xiaoyan Deng,Yubin Xing
出处
期刊:Biorheology
[IOS Press]
日期:2021-03-05
卷期号:58 (1-2): 27-38
被引量:2
摘要
BACKGROUND: Heart failure (HF) is a common disease globally. Ventricular assist devices (VADs) are widely used to treat HF. In contrast to the natural heart, different VADs generate different blood flow waves in the aorta. OBJECTIVE: To explore whether the different inflow rate waveforms from the ascending aorta generate far-reaching hemodynamic influences on the human aortic arch. METHODS: An aortic geometric model was reconstructed based on computed tomography data of a patient with HF. A total of five numerical simulations were conducted, including a case with the inflow rate waveforms from the ascending aorta with normal physiological conditions, two HF, and two with typical VAD support. The hemodynamic parameters, wall shear stress (WSS), oscillatory shear index (OSI), relative residence time (RRT), and the strength of the helical flow, were calculated. RESULTS: In contrast to the natural heart, numerical simulations showed that HF decreased WSS and induced higher OSI and RRT. Moreover, HF weakened helical flow strength. Pulsatile flow VADs that elevated the WSS, induced some helical flow, while continuous flow VADs could not. CONCLUSIONS: HF leads to an adverse hemodynamic environment by decreasing WSS and reducing the helical flow strength. Based upon hemodynamic effects, pulsatile flow VADs may be more advantageous than continuous flow VADs. Thus, pulsatile flow VADs may be a better option for patients with HF.
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