睑板腺
脂类学
鞘磷脂
糖尿病
内分泌学
内科学
2型糖尿病
脂质代谢
神经酰胺
炎症
脂质信号
脂滴
脂质体
化学
泡沫电池
生物
细胞凋亡
医学
胆固醇
生物化学
脂蛋白
眼科
眼睑
作者
Huifeng Wang,Qingjun Zhou,Luqin Wan,Menglong Guo,Chen Chen,Jun‐Fa Xue,Lingling Yang,Lixin Xie
标识
DOI:10.1016/j.exer.2021.108710
摘要
Diabetes is a significant risk factor for meibomian gland dysfunction (MGD), but its mechanism is poorly understood. The main function of the meibomian glands (MGs) is to synthesize, store, and secrete lipids. In this study, we found that the amount of lipids in the meibomian acini in STZ-induced type 1 diabetic mice decreased, and the lipid droplets became larger and irregular. In all, 31 lipid subclasses were identified in the mouse MGs, which contained 1378 lipid species in total through lipidomics analysis based on LC-MS/MS. Diabetes caused a significant increase in the content of ceramides (Cer) in the MGs but a significant decrease in the ration of sphingomyelin to ceramides (SM/Cer). The quantity of meibocytes in diabetic mice was dramatically decreased, and the proliferation activity was alleviated, which may be associated with cell cycle arrest caused by diabetes-induced abnormal Cer metabolism in MGs. We found an increase in macrophage and neutrophils infiltration in the diabetic MGs, which may be related to the significant reduction of AcCa in diabetic MGs. Taken together, the results of the present study demonstrated that diabetes induced disruption of lipid homeostasis in MGs, which may mediate the decreased cell proliferation and increased inflammation caused by diabetes in MGs.
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