Lipidomic analysis of meibomian glands from type-1 diabetes mouse model and preliminary studies of potential mechanism

睑板腺 脂类学 鞘磷脂 糖尿病 内分泌学 内科学 2型糖尿病 脂质代谢 神经酰胺 炎症 脂质信号 脂滴 脂质体 化学 泡沫电池 生物 细胞凋亡 医学 胆固醇 生物化学 脂蛋白 眼科 眼睑
作者
Huifeng Wang,Qingjun Zhou,Luqin Wan,Menglong Guo,Chen Chen,Jun‐Fa Xue,Lingling Yang,Lixin Xie
出处
期刊:Experimental Eye Research [Elsevier]
卷期号:210: 108710-108710 被引量:9
标识
DOI:10.1016/j.exer.2021.108710
摘要

Diabetes is a significant risk factor for meibomian gland dysfunction (MGD), but its mechanism is poorly understood. The main function of the meibomian glands (MGs) is to synthesize, store, and secrete lipids. In this study, we found that the amount of lipids in the meibomian acini in STZ-induced type 1 diabetic mice decreased, and the lipid droplets became larger and irregular. In all, 31 lipid subclasses were identified in the mouse MGs, which contained 1378 lipid species in total through lipidomics analysis based on LC-MS/MS. Diabetes caused a significant increase in the content of ceramides (Cer) in the MGs but a significant decrease in the ration of sphingomyelin to ceramides (SM/Cer). The quantity of meibocytes in diabetic mice was dramatically decreased, and the proliferation activity was alleviated, which may be associated with cell cycle arrest caused by diabetes-induced abnormal Cer metabolism in MGs. We found an increase in macrophage and neutrophils infiltration in the diabetic MGs, which may be related to the significant reduction of AcCa in diabetic MGs. Taken together, the results of the present study demonstrated that diabetes induced disruption of lipid homeostasis in MGs, which may mediate the decreased cell proliferation and increased inflammation caused by diabetes in MGs.
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