病毒
病毒学
甲型流感病毒
生物
H5N1亚型流感病毒
正粘病毒科
大流行
血凝素(流感)
H5N1基因结构
神经氨酸酶
流感疫苗
病毒复制
重新分配
反向遗传学
作者
Fanhua Wei,Chengjiang Gao,Yujiong Wang
标识
DOI:10.1080/1040841x.2021.1960482
摘要
Influenza viruses are one of the leading causes of respiratory tract infections in humans and their newly emerging and re-emerging virus strains are responsible for seasonal epidemics and occasional pandemics, leading to a serious threat to global public health systems. The poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models are often associated with elevated proinflammatory cytokines and chemokines production, which is also known as hypercytokinemia or storm, that precedes acute respiratory distress syndrome (ARDS) and often leads to death. Although we still do not fully understand the complex nature of cytokine storms, the use of immunomodulatory drugs is a promising approach for treating hypercytokinemia induced by an acute viral infection, including highly pathogenic avian influenza virus infection and Coronavirus Disease 2019 (COVID-19). This review aims to discuss the immune responses and cytokine storm pathology induced by influenza virus infection and also summarize alternative experimental strategies for treating hypercytokinemia caused by influenza virus.
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